› 1ksq

Solution NMR

NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1

Released:
DOI: 10.2210/pdb1ksq/pdb
PDB entry 1ksq coloured by chain, ensemble of 20 models, front view.
PDB entry 1ksq coloured by chain, ensemble of 20 models, side view.
PDB entry 1ksq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta.
Lack J, O'Leary JM, Knott V, Yuan X, Rifkin DB, Handford PA, Downing AK
J Mol Biol 334 281-91 (2003)
PMID: 14607119

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172095 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Latent-transforming growth factor beta-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 75 amino acids
Theoretical weight: 8.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q14766 (Residues: 1340-1412; Coverage: 4%)
Gene name: LTBP1
Sequence domains: TB domain
Structure domains: TGF-beta binding (TB) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

13 review citations

Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability.
Rifkin DB. (2005)
12 more

4 mentions without citation

NMR spectroscopic and bioinformatic analyses of the LTBP1 C-terminus reveal a highly dynamic domain organisation.
Robertson et al. (2014)
3 more