› 1kth

X-ray diffraction
0.95Å resolution

The Anisotropic Refinement Of Kunitz Type Domain C5 at 0.95 Angstrom

Released:
DOI: 10.2210/pdb1kth/pdb
PDB entry 1kth coloured by chain, front view.
PDB entry 1kth coloured by chain, side view.
PDB entry 1kth coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Anisotropic behaviour of the C-terminal Kunitz-type domain of the alpha3 chain of human type VI collagen at atomic resolution (0.9 A).
Arnoux B, Ducruix A, Prangé T
Acta Crystallogr D Biol Crystallogr 58 1252-4 (2002)
PMID: 12077460

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146098 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagen alpha-3(VI) chain Chain: A
Molecule details ›
Chain: A
Length: 58 amino acids
Theoretical weight: 6.64 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P12111 (Residues: 3108-3165; Coverage: 2%)
Gene name: COL6A3
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

1 bound ligand:
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: P21
Unit cell:
a: 25.27Å b: 37.8Å c: 28.51Å
α: 90° β: 109.42° γ: 90°
R-values:
R R work R free
0.139 0.135 0.167
Expression system: Saccharomyces cerevisiae

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Citations

3 review citations

Collagen VI related muscle disorders.
Lampe et al. (2005)
2 more

13 mentions without citation

In vitro-engineered non-antibody protein therapeutics.
Simeon et al. (2018)
12 more