Function and Biology Details
Reaction catalysed:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
TGF-beta-3 complex and TGF-beta receptor type-2 (preferred)
PDBe Complex ID:
PDB-CPX-145357 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transforming growth factor beta-3
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 12.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Length: 112 amino acids
Theoretical weight: 12.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P10600 (Residues: 301-412; Coverage: 29%)
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
TGF-beta receptor type-2
Molecule details ›
Chain: B
Length: 122 amino acids
Theoretical weight: 13.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Transforming growth factor beta receptor 2 ectodomain
Structure domains: CD59
Length: 122 amino acids
Theoretical weight: 13.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P37173 (Residues: 38-159; Coverage: 22%)
Sequence domains: Transforming growth factor beta receptor 2 ectodomain
Structure domains: CD59
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X8C
Spacegroup:
R32
Expression system: Escherichia coli
