› 1kup

Solution NMR

Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins

Released:
DOI: 10.2210/pdb1kup/pdb
PDB entry 1kup coloured by chain, ensemble of 20 models, front view.
PDB entry 1kup coloured by chain, ensemble of 20 models, side view.
PDB entry 1kup coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits.
Weljie AM, Hwang PM, Vogel HJ
Proc Natl Acad Sci U S A 99 5878-83 (2002)
PMID: 11983888

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138441 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin alpha-IIb light chain, form 2 Chain: A
Molecule details ›
Chain: A
Length: 11 amino acids
Theoretical weight: 1.47 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08514 (Residues: 1018-1028; Coverage: 1%)
Gene names: GP2B, ITGA2B, ITGAB
Sequence domains: Integrin alpha cytoplasmic region
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 25 amino acids
Theoretical weight: 3.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05106 (Residues: 742-766; Coverage: 3%)
Gene names: GP3A, ITGB3
Sequence domains: Integrin beta cytoplasmic domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics, matrix relaxation, torsion angle dynamics
Expression system: Not provided

Quick links

Citations

28 review citations

Integrins: bidirectional, allosteric signaling machines.
Hynes RO. (2002)
27 more

1 mention without citation

Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits.
Weljie et al. (2002)