› 1kxg

X-ray diffraction
2Å resolution

The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.

Released:
DOI: 10.2210/pdb1kxg/pdb
PDB entry 1kxg coloured by chain, front view.
PDB entry 1kxg coloured by chain, side view.
PDB entry 1kxg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of BLyS receptor recognition.
Oren DA, Li Y, Volovik Y, Morris TS, Dharia C, Das K, Galperina O, Gentz R, Arnold E
Nat Struct Biol 9 288-92 (2002)
PMID: 11862220

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195109 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 13b, soluble form Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 152 amino acids
Theoretical weight: 17.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y275 (Residues: 134-285; Coverage: 53%)
Gene names: BAFF, BLYS, TALL1, TNFSF13B, TNFSF20, UNQ401/PRO738, ZTNF4
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand MG 7 x MG
Ligand CIT 2 x CIT
Ligand DIO 20 x DIO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P65
Unit cell:
a: 123.58Å b: 123.58Å c: 161.23Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.189 0.209
Expression system: Spodoptera frugiperda

Quick links

Citations

17 review citations

BAFF AND APRIL: a tutorial on B cell survival.
Mackay et al. (2003)
16 more

4 mentions without citation

An expanded benchmark for antibody-antigen docking and affinity prediction reveals insights into antibody recognition determinants.
Guest et al. (2021)
3 more