› 1kxu

X-ray diffraction
2.6Å resolution

CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE

Released:
DOI: 10.2210/pdb1kxu/pdb
PDB entry 1kxu coloured by chain, front view.
PDB entry 1kxu coloured by chain, side view.
PDB entry 1kxu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase.
Kim KK, Chamberlin HM, Morgan DO, Kim SH
Nat Struct Biol 3 849-55 (1996)
PMID: 8836101

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156436 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-H Chain: A
Molecule details ›
Chain: A
Length: 333 amino acids
Theoretical weight: 38.89 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P51946 (Residues: 1-323; Coverage: 100%)
Gene name: CCNH
Sequence domains:
Structure domains: Cyclin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL1-5
Spacegroup: I4122
Unit cell:
a: 84.08Å b: 84.08Å c: 374.88Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.295
Expression system: Spodoptera frugiperda

Quick links

Citations

11 review citations

Cyclin-dependent kinases: engines, clocks, and microprocessors.
Morgan DO. (1997)
10 more

12 mentions without citation

XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase.
Fuss et al. (2011)
11 more