› 1kyn

X-ray diffraction
3.5Å resolution

Function and Biology Details

Reaction catalysed: 
Specificity similar to chymotrypsin C.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140091 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin G Chains: A, B
Molecule details ›
Chains: A, B
Length: 235 amino acids
Theoretical weight: 26.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08311 (Residues: 21-255; Coverage: 99%)
Gene name: CTSG
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand KTP 2 x KTP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P41
Unit cell:
a: 59.44Å b: 59.44Å c: 130.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.258 0.258 0.328

Quick links

Citations

1 review citation

Inhibitors of cathepsin G: a patent review (2005 to present).
Kosikowska et al. (2013)
18 other articles

4 mentions without citation

Proteomic profiling change during the early development of silicosis disease.
Miao et al. (2016)
3 more