› 1l8k

X-ray diffraction
2.56Å resolution

T Cell Protein-Tyrosine Phosphatase Structure

Released:
DOI: 10.2210/pdb1l8k/pdb
PDB entry 1l8k coloured by chain, front view.
PDB entry 1l8k coloured by chain, side view.
PDB entry 1l8k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure determination of T cell protein-tyrosine phosphatase.
Iversen LF, Moller KB, Pedersen AK, Peters GH, Petersen AS, Andersen HS, Branner S, Mortensen SB, Moller NP
J Biol Chem 277 19982-90 (2002)
PMID: 11907034

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148138 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 2 Chain: A
Molecule details ›
Chain: A
Length: 314 amino acids
Theoretical weight: 36.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17706 (Residues: 1-314; Coverage: 76%)
Gene names: PTPN2, PTPT
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P43212
Unit cell:
a: 60.494Å b: 60.494Å c: 187.633Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.215 0.288
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Protein tyrosine phosphatase 1B inhibitors for diabetes.
Johnson et al. (2002)
19 more

17 mentions without citation

Protein tyrosine phosphatases: structure, function, and implication in human disease.
Tautz et al. (2013)
16 more