› 1lfg

X-ray diffraction
2.2Å resolution

Structure of diferric human lactoferrin

Released:
DOI: 10.2210/pdb1lfg/pdb
PDB entry 1lfg coloured by chain, front view.
PDB entry 1lfg coloured by chain, side view.
PDB entry 1lfg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human diferric lactoferrin refined at 2.2 A resolution.
Haridas M, Anderson BF, Baker EN
Acta Crystallogr D Biol Crystallogr 51 629-46 (1995)
PMID: 15299793

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Lactotransferrin Chain: A
Molecule details ›
Chain: A
Length: 691 amino acids
Theoretical weight: 76.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02788 (Residues: 20-710; Coverage: 100%)
Gene names: GIG12, LF, LTF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand FE 2 x FE
Ligand CO3 2 x CO3
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 156.26Å b: 97.4Å c: 55.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 not available not available
Expression system: Not provided

Quick links

Citations

12 review citations

Lactoferrin a multiple bioactive protein: an overview.
García-Montoya et al. (2012)
11 more

44 mentions without citation

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications.
Spicer et al. (2018)
43 more