› 1lj7

X-ray diffraction
3.15Å resolution

Crystal structure of calcium-depleted human C-reactive protein from perfectly twinned data

Released:
DOI: 10.2210/pdb1lj7/pdb
PDB entry 1lj7 coloured by chain, front view.
PDB entry 1lj7 coloured by chain, side view.
PDB entry 1lj7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The three-dimensional structure of calcium-depleted human C-reactive protein from perfectly twinned crystals.
Ramadan MA, Shrive AK, Holden D, Myles DA, Volanakis JE, DeLucas LJ, Greenhough TJ
Acta Crystallogr D Biol Crystallogr 58 992-1001 (2002)
PMID: 12037301

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136120 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-reactive protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 206 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02741 (Residues: 19-224; Coverage: 100%)
Gene names: CRP, PTX1
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX7.2
Spacegroup: P43
Unit cell:
a: 102.31Å b: 102.31Å c: 309.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 0.199

Quick links

Citations

5 review citations

Structural and functional anatomy of the globular domain of complement protein C1q.
Kishore et al. (2004)
4 more

4 mentions without citation

C-reactive protein exists in an NaCl concentration-dependent pentamer-decamer equilibrium in physiological buffer.
Okemefuna et al. (2010)
3 more