Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Ubiquitin-like domain
- SKP1/BTB/POZ domain superfamily
- von Hippel-Lindau disease tumour suppressor, alpha domain
- von Hippel-Lindau disease tumour suppressor, alpha domain superfamily
- von Hippel-Lindau disease tumour suppressor, beta/alpha domain
- von Hippel-Lindau disease tumour suppressor, beta domain superfamily
- von Hippel-Lindau disease tumour suppressor, beta domain
- VHL superfamily
6 more domains
Structure domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Hypoxia-Inducible Factors (preferred)
PDBe Complex ID:
PDB-CPX-154087 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Elongin-B
Molecule details ›
Chain: B
Length: 118 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Length: 118 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q15370 (Residues: 1-118; Coverage: 100%)
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Elongin-C
Molecule details ›
Chain: C
Length: 96 amino acids
Theoretical weight: 10.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Skp1 family, tetramerisation domain
Structure domains: Potassium Channel Kv1.1; Chain A
Length: 96 amino acids
Theoretical weight: 10.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q15369 (Residues: 17-112; Coverage: 86%)
Sequence domains: Skp1 family, tetramerisation domain
Structure domains: Potassium Channel Kv1.1; Chain A
von Hippel-Lindau disease tumor suppressor
Molecule details ›
Chain: V
Length: 160 amino acids
Theoretical weight: 18.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains:
Length: 160 amino acids
Theoretical weight: 18.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P40337 (Residues: 54-213; Coverage: 75%)
Sequence domains:
Structure domains:
Hypoxia-inducible factor 1-alpha
Molecule details ›
Chain: H
Length: 20 amino acids
Theoretical weight: 2.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Hypoxia-inducible factor-1
Length: 20 amino acids
Theoretical weight: 2.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: Q16665 (Residues: 556-575; Coverage: 2%)
Sequence domains: Hypoxia-inducible factor-1
