› 1ln2

X-ray diffraction
2.9Å resolution

Crystal Structure of Human Phosphatidylcholine Transfer Protein in Complex with Dilinoleoylphosphatidylcholine (Seleno-Met Protein)

Released:
DOI: 10.2210/pdb1ln2/pdb
PDB entry 1ln2 coloured by chain, front view.
PDB entry 1ln2 coloured by chain, side view.
PDB entry 1ln2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human phosphatidylcholine transfer protein in complex with its ligand.
Roderick SL, Chan WW, Agate DS, Olsen LR, Vetting MW, Rajashankar KR, Cohen DE
Nat Struct Biol 9 507-11 (2002)
PMID: 12055623

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193854 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylcholine transfer protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 214 amino acids
Theoretical weight: 25.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKL6 (Residues: 1-214; Coverage: 100%)
Gene names: PCTP, STARD2
Sequence domains: START domain
Structure domains: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4

Ligands and Environments

1 bound ligand:
Ligand DLP 2 x DLP
1 modified residue:
Ligand MSE 14 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A
Spacegroup: P4212
Unit cell:
a: 134.7Å b: 134.7Å c: 82.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.231 0.293
Expression system: Escherichia coli

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Citations

29 review citations

Early steps in steroidogenesis: intracellular cholesterol trafficking.
Miller et al. (2011)
28 more

5 mentions without citation

Computational Modeling of Hepatitis C Virus Envelope Glycoprotein Structure and Recognition.
Guest et al. (2018)
4 more