› 1lo1

Solution NMR

ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA

Released:
DOI: 10.2210/pdb1lo1/pdb
PDB entry 1lo1 coloured by chain, ensemble of 20 models, front view.
PDB entry 1lo1 coloured by chain, ensemble of 20 models, side view.
PDB entry 1lo1 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition.
Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE
J Mol Biol 327 819-32 (2003)
PMID: 12654265

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114143 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Steroid hormone receptor ERR2 Chain: A
Molecule details ›
Chain: A
Length: 98 amino acids
Theoretical weight: 11.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95718 (Residues: 97-194; Coverage: 23%)
Gene names: ERRB2, ESRL2, ESRRB, NR3B2
Sequence domains: Zinc finger, C4 type (two domains)
Structure domains: Erythroid Transcription Factor GATA-1, subunit A
5'-D(*GP*CP*TP*CP*AP*AP*GP*GP*TP*CP*AP*CP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 13 nucleotides
Theoretical weight: 3.98 KDa
Source organism: Homo sapiens
Expression system: Not provided
5'-D(*CP*GP*TP*GP*AP*CP*CP*TP*TP*GP*AP*GP*C)-3' Chain: C
Molecule details ›
Chain: C
Length: 13 nucleotides
Theoretical weight: 3.97 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

21 review citations

Structure-function relationship of estrogen receptor alpha and beta: impact on human health.
Ascenzi et al. (2006)
20 more

7 mentions without citation

Estrogen-related receptor β (ERRβ) - renaissance receptor or receptor renaissance?
Divekar et al. (2016)
6 more