› 1lpe

X-ray diffraction
2.25Å resolution

THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E

Released:
DOI: 10.2210/pdb1lpe/pdb
PDB entry 1lpe coloured by chain, front view.
PDB entry 1lpe coloured by chain, side view.
PDB entry 1lpe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.
Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA
Science 252 1817-22 (1991)
PMID: 2063194

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135991 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein E Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 16.74 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02649 (Residues: 41-184; Coverage: 48%)
Gene name: APOE
Sequence domains: Apolipoprotein A1/A4/E domain
Structure domains: Apolipoprotein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 40.65Å b: 53.96Å c: 85.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.175 not available
Expression system: Not provided

Quick links

Citations

78 review citations

Apolipoprotein E: far more than a lipid transport protein.
Mahley et al. (2000)
77 more

16 mentions without citation

Apolipoprotein E: from lipid transport to neurobiology.
Hauser et al. (2011)
15 more