› 1lsl

X-ray diffraction
1.9Å resolution

Crystal Structure of the Thrombospondin-1 Type 1 Repeats

Released:
DOI: 10.2210/pdb1lsl/pdb
PDB entry 1lsl coloured by chain, front view.
PDB entry 1lsl coloured by chain, side view.
PDB entry 1lsl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication.
Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH
J Cell Biol 159 373-82 (2002)
PMID: 12391027

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thrombospondin-1 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.18 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: P07996 (Residues: 434-546; Coverage: 10%)
Gene names: THBS1, TSP, TSP1
Sequence domains: Thrombospondin type 1 domain
Structure domains: Thrombospondin type-1 (TSP1) repeat

Ligands and Environments

2 bound ligands:
Ligand FUL 1 x FUL
Ligand FUC 1 x FUC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 67.63Å b: 84.41Å c: 37.17Å
α: 90° β: 108.67° γ: 90°
R-values:
R R work R free
0.235 0.238 0.282
Expression system: Drosophila

Quick links

Citations

37 review citations

The thrombospondins.
Adams et al. (2004)
36 more

30 mentions without citation

The CCN family of proteins: structure-function relationships.
Holbourn et al. (2008)
29 more