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X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF PHOSPHOGLYCERATE KINASE FROM PLASMODIUM FALCIPARUM, IN THE OPEN CONFORMATION

Released:
DOI: 10.2210/pdb1ltk/pdb
PDB entry 1ltk coloured by chain, front view.
PDB entry 1ltk coloured by chain, side view.
PDB entry 1ltk coloured by chain, top view.
Source organism: Plasmodium falciparum
Entry authors: Chattopadhyay D, Pal B, Smith CD

Function and Biology Details

Reaction catalysed: 
ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150986 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoglycerate kinase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 425 amino acids
Theoretical weight: 47.02 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: P27362 (Residues: 2-416; Coverage: 100%)
Gene names: PFI1105w, PGK
Sequence domains: Phosphoglycerate kinase
Structure domains: Phosphoglycerate kinase, N-terminal domain

Ligands and Environments

3 bound ligands:
Ligand SO4 3 x SO4
Ligand AMP 3 x AMP
Ligand GOL 1 x GOL
1 modified residue:
Ligand MSE 27 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I222
Unit cell:
a: 119.03Å b: 147.61Å c: 206.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.284 0.208 0.258
Expression system: Escherichia coli

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