› 1lxi

X-ray diffraction
2Å resolution

Refinement of BMP7 crystal structure

Released:
DOI: 10.2210/pdb1lxi/pdb
PDB entry 1lxi coloured by chain, front view.
PDB entry 1lxi coloured by chain, side view.
PDB entry 1lxi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.
Greenwald J, Groppe J, Gray P, Wiater E, Kwiatkowski W, Vale W, Choe S
Mol Cell 11 605-17 (2003)
PMID: 12667445

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148281 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone morphogenetic protein 7 Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P18075 (Residues: 293-431; Coverage: 35%)
Gene names: BMP7, OP1
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P3221
Unit cell:
a: 101.294Å b: 101.294Å c: 41.812Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.229 0.228 0.244
Expression system: Cricetulus griseus

Quick links

Citations

55 review citations

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Shi et al. (2003)
54 more

9 mentions without citation

The CCN family of proteins: structure-function relationships.
Holbourn et al. (2008)
8 more