› 1m39

Solution NMR

Solution structure of the C-terminal fragment (F86-I165) of the human centrin 2 in calcium saturated form

Released:
DOI: 10.2210/pdb1m39/pdb
PDB entry 1m39 coloured by chain, ensemble of 25 models, front view.
PDB entry 1m39 coloured by chain, ensemble of 25 models, side view.
PDB entry 1m39 coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain.
Matei E, Miron S, Blouquit Y, Duchambon P, Durussel I, Cox JA, Craescu CT
Biochemistry 42 1439-50 (2003)
PMID: 12578356

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154328 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Centrin-2 Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 10.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41208 (Residues: 84-172; Coverage: 52%)
Gene names: CALT, CEN2, CETN2
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, restraint energy minimization
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Centrins in retinal photoreceptor cells: regulators in the connecting cilium.
Trojan et al. (2008)
7 more

2 mentions without citation

Exploring NMR ensembles of calcium binding proteins: perspectives to design inhibitors of protein-protein interactions.
Isvoran et al. (2011)
1 more