› 1m9z

X-ray diffraction
1.05Å resolution

CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN

Released:
DOI: 10.2210/pdb1m9z/pdb
PDB entry 1m9z coloured by chain, front view.
PDB entry 1m9z coloured by chain, side view.
PDB entry 1m9z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The 1.1 A crystal structure of human TGF-beta type II receptor ligand binding domain.
Boesen CC, Radaev S, Motyka SA, Patamawenu A, Sun PD
Structure 10 913-9 (2002)
PMID: 12121646

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153364 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-2 Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 12.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37173 (Residues: 49-159; Coverage: 20%)
Gene name: TGFBR2
Sequence domains: Transforming growth factor beta receptor 2 ectodomain
Structure domains: CD59

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P212121
Unit cell:
a: 35.471Å b: 40.658Å c: 76.154Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.156 0.166
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Shi et al. (2003)
8 more

20 mentions without citation

Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism.
Hinck AP. (2018)
19 more