› 1mc7

Solution NMR

Solution Structure of mDvl1 PDZ domain

Released:
DOI: 10.2210/pdb1mc7/pdb
PDB entry 1mc7 coloured by chain, ensemble of 20 models, front view.
PDB entry 1mc7 coloured by chain, ensemble of 20 models, side view.
PDB entry 1mc7 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.
Wong HC, Bourdelas A, Krauss A, Lee HJ, Shao Y, Wu D, Mlodzik M, Shi DL, Zheng J
Mol Cell 12 1251-60 (2003)
PMID: 14636582

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156295 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Segment polarity protein dishevelled homolog DVL-1 Chain: A
Molecule details ›
Chain: A
Length: 95 amino acids
Theoretical weight: 10.2 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P51141 (Residues: 251-345; Coverage: 14%)
Gene names: Dvl, Dvl1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

108 review citations

The Wnt signaling pathway in development and disease.
Logan et al. (2004)
107 more

4 mentions without citation

The structural biology of canonical Wnt signalling.
Agostino et al. (2020)
3 more