› 1mjn

X-ray diffraction
1.3Å resolution

Crystal Structure of the intermediate affinity aL I domain mutant

Released:
DOI: 10.2210/pdb1mjn/pdb
PDB entry 1mjn coloured by chain, front view.
PDB entry 1mjn coloured by chain, side view.
PDB entry 1mjn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.
Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, Jun CD, McCormack A, Zhang R, Joachimiak A, Takagi J, Wang JH, Springer TA
Cell 112 99-111 (2003)
PMID: 12526797

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149031 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-L Chain: A
Molecule details ›
Chain: A
Length: 179 amino acids
Theoretical weight: 20.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20701 (Residues: 153-331; Coverage: 16%)
Gene names: CD11A, ITGAL
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 40.374Å b: 57.399Å c: 66.909Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.156 0.202
Expression system: Escherichia coli

Quick links

Citations

98 review citations

Structural basis of integrin regulation and signaling.
Luo et al. (2007)
97 more

12 mentions without citation

Rolling cell adhesion.
McEver et al. (2010)
11 more