› 1mp8

X-ray diffraction
1.6Å resolution

Crystal structure of Focal Adhesion Kinase (FAK)

Released:
DOI: 10.2210/pdb1mp8/pdb
PDB entry 1mp8 coloured by chain, front view.
PDB entry 1mp8 coloured by chain, side view.
PDB entry 1mp8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.
Nowakowski J, Cronin CN, McRee DE, Knuth MW, Nelson CG, Pavletich NP, Rogers J, Sang BC, Scheibe DN, Swanson RV, Thompson DA
Structure 10 1659-67 (2002)
PMID: 12467573

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 281 amino acids
Theoretical weight: 32.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05397 (Residues: 411-686; Coverage: 26%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P21
Unit cell:
a: 45.189Å b: 46.636Å c: 62.225Å
α: 90° β: 80.57° γ: 90°
R-values:
R R work R free
0.188 0.179 0.23
Expression system: Spodoptera frugiperda

Quick links

Citations

25 review citations

Focal adhesion kinase: in command and control of cell motility.
Mitra et al. (2005)
24 more

15 mentions without citation

Structural basis for the autoinhibition of focal adhesion kinase.
Lietha et al. (2007)
14 more