› 1mpu

X-ray diffraction
2.5Å resolution

Crystal Structure of the free human NKG2D immunoreceptor

Released:
DOI: 10.2210/pdb1mpu/pdb
PDB entry 1mpu coloured by chain, front view.
PDB entry 1mpu coloured by chain, side view.
PDB entry 1mpu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands.
McFarland BJ, Kortemme T, Yu SF, Baker D, Strong RK
Structure 11 411-22 (2003)
PMID: 12679019

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150834 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NKG2-D type II integral membrane protein Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26718 (Residues: 79-216; Coverage: 64%)
Gene names: D12S2489E, KLRK1, NKG2D
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P41212
Unit cell:
a: 87.65Å b: 87.65Å c: 36.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.245 0.296
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

25 review citations

Roles of the NKG2D immunoreceptor and its ligands.
Raulet DH. (2003)
24 more

4 mentions without citation

T Cell Activation Machinery: Form and Function in Natural and Engineered Immune Receptors.
Chandler et al. (2020)
3 more