› 1mr8

X-ray diffraction
1.9Å resolution

MIGRATION INHIBITORY FACTOR-RELATED PROTEIN 8 FROM HUMAN

Released:
DOI: 10.2210/pdb1mr8/pdb
PDB entry 1mr8 coloured by chain, front view.
PDB entry 1mr8 coloured by chain, side view.
PDB entry 1mr8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human MRP8, a member of the S100 calcium-binding protein family, by MAD phasing at 1.9 A resolution.
Ishikawa K, Nakagawa A, Tanaka I, Suzuki M, Nishihira J
Acta Crystallogr D Biol Crystallogr 56 559-66 (2000)
PMID: 10771424

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-138504 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 93 amino acids
Theoretical weight: 10.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05109 (Residues: 1-93; Coverage: 100%)
Gene names: CAGA, CFAG, MRP8, S100A8
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6B
Spacegroup: P3121
Unit cell:
a: 52.5Å b: 52.5Å c: 128.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.193 0.234

Quick links

Citations

12 review citations

S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.
Donato R. (2001)
11 more

17 mentions without citation

Computational Approaches to Toll-Like Receptor 4 Modulation.
Billod et al. (2016)
16 more