› 1muo

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE

Released:
DOI: 10.2210/pdb1muo/pdb
PDB entry 1muo coloured by chain, front view.
PDB entry 1muo coloured by chain, side view.
PDB entry 1muo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of aurora-2, an oncogenic serine/threonine kinase.
Cheetham GM, Knegtel RM, Coll JT, Renwick SB, Swenson L, Weber P, Lippke JA, Austen DA
J Biol Chem 277 42419-22 (2002)
PMID: 12237287

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 297 amino acids
Theoretical weight: 34.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14965 (Residues: 107-403; Coverage: 74%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ADN 1 x ADN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup: P3221
Unit cell:
a: 86.2Å b: 86.2Å c: 75.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.26 0.24 0.29

Quick links

Citations

24 review citations

The cellular geography of aurora kinases.
Carmena et al. (2003)
23 more

11 mentions without citation

Substrate and docking interactions in serine/threonine protein kinases.
Goldsmith et al. (2007)
10 more