› 1mw4

Solution NMR

Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139

Released:
DOI: 10.2210/pdb1mw4/pdb
PDB entry 1mw4 coloured by chain, ensemble of 10 models, front view.
PDB entry 1mw4 coloured by chain, ensemble of 10 models, side view.
PDB entry 1mw4 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2.
Ivancic M, Daly RJ, Lyons BA
J Biomol NMR 27 205-19 (2003)
PMID: 12975581

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138069 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth factor receptor-bound protein 7 Chain: A
Molecule details ›
Chain: A
Length: 120 amino acids
Theoretical weight: 13.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14451 (Residues: 415-532; Coverage: 22%)
Gene name: GRB7
Sequence domains: SH2 domain
Structure domains: SH2 domain
Receptor tyrosine-protein kinase erbB-2 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04626 (Residues: 1135-1144; Coverage: 1%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

4 review citations

Grb10 and Grb14: enigmatic regulators of insulin action--and more?
Holt et al. (2005)
3 more

7 mentions without citation

Loops govern SH2 domain specificity by controlling access to binding pockets.
Kaneko et al. (2010)
6 more