› 1mwn

Solution NMR

Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12

Released:
DOI: 10.2210/pdb1mwn/pdb
PDB entry 1mwn coloured by chain, ensemble of 20 models, front view.
PDB entry 1mwn coloured by chain, ensemble of 20 models, side view.
PDB entry 1mwn coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12.
Inman KG, Yang R, Rustandi RR, Miller KE, Baldisseri DM, Weber DJ
J Mol Biol 324 1003-14 (2002)
PMID: 12470955

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138095 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein S100-B Chains: A, B
Molecule details ›
Chains: A, B
Length: 92 amino acids
Theoretical weight: 10.76 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P04631 (Residues: 1-92; Coverage: 100%)
Gene name: S100b
Sequence domains:
Structure domains: EF-hand
F-actin-capping protein subunit alpha-1 Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 12 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P52907 (Residues: 265-276; Coverage: 4%)
Gene name: CAPZA1

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

7 review citations

S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature).
Marenholz et al. (2004)
6 more

13 mentions without citation

The evolution of S100B inhibitors for the treatment of malignant melanoma.
Hartman et al. (2013)
12 more