› 1mx3

X-ray diffraction
1.95Å resolution

Crystal structure of CtBP dehydrogenase core holo form

Released:
DOI: 10.2210/pdb1mx3/pdb
PDB entry 1mx3 coloured by chain, front view.
PDB entry 1mx3 coloured by chain, side view.
PDB entry 1mx3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase.
Kumar V, Carlson JE, Ohgi KA, Edwards TA, Rose DW, Escalante CR, Rosenfeld MG, Aggarwal AK
Mol Cell 10 857-69 (2002)
PMID: 12419229

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-171655 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-terminal-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 347 amino acids
Theoretical weight: 38.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13363 (Residues: 28-353; Coverage: 74%)
Gene names: CTBP, CTBP1
Sequence domains:
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

2 bound ligands:
Ligand NAD 1 x NAD
Ligand ACY 1 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25, APS BEAMLINE 32-ID
Spacegroup: P6422
Unit cell:
a: 89.1Å b: 89.1Å c: 164Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.211 0.253
Expression system: Escherichia coli

Quick links

Citations

35 review citations

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.
Kavanagh et al. (2008)
34 more

11 mentions without citation

Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor.
Fjeld et al. (2003)
10 more