› 1mx6

X-ray diffraction
2Å resolution

Structure of p18INK4c (F92N)

Released:
DOI: 10.2210/pdb1mx6/pdb
PDB entry 1mx6 coloured by chain, front view.
PDB entry 1mx6 coloured by chain, side view.
PDB entry 1mx6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity.
Venkataramani RN, MacLachlan TK, Chai X, El-Deiry WS, Marmorstein R
J Biol Chem 277 48827-33 (2002)
PMID: 12370184

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154868 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 4 inhibitor C Chains: A, B
Molecule details ›
Chains: A, B
Length: 168 amino acids
Theoretical weight: 18.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P42773 (Residues: 1-168; Coverage: 100%)
Gene names: CDKN2C, CDKN6
Sequence domains: Ankyrin repeats (3 copies)
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21212
Unit cell:
a: 55.005Å b: 150.843Å c: 40.574Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.237 0.263
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Selectivity and potency of cyclin-dependent kinase inhibitors.
Sridhar et al. (2006)
7 other articles

2 mentions without citation

A primer on ankyrin repeat function in TRP channels and beyond.
Gaudet R. (2008)
1 more