› 1mzi

Solution NMR

Solution ensemble structures of HIV-1 gp41 2F5 mAb epitope

Released:
DOI: 10.2210/pdb1mzi/pdb
PDB entry 1mzi coloured by chain, ensemble of 81 models, front view.
PDB entry 1mzi coloured by chain, ensemble of 81 models, side view.
PDB entry 1mzi coloured by chain, ensemble of 81 models, top view.
Source organism: HIV-1 M:B_HXB2R
Primary publication:
Structural analysis of the epitope of the anti-HIV antibody 2F5 sheds light into its mechanism of neutralization and HIV fusion.
Barbato G, Bianchi E, Ingallinella P, Hurni WH, Miller MD, Ciliberto G, Cortese R, Bazzo R, Shiver JW, Pessi A
J Mol Biol 330 1101-15 (2003)
PMID: 12860131

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137921 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chain: A
Molecule details ›
Chain: A
Length: 13 amino acids
Theoretical weight: 1.62 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 659-671; Coverage: 2%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Ensemble generation with MEDUSA, Clustering analysis with NMRCLUST, Statistical analysis of the ensemble with NAMFIS
Expression system: Not provided

Quick links

Citations

9 review citations

The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design.
Montero et al. (2008)
8 more

2 mentions without citation

Structure and immunogenicity of a peptide vaccine, including the complete HIV-1 gp41 2F5 epitope: implications for antibody recognition mechanism and immunogen design.
Serrano et al. (2014)
1 more