› 1n0n

X-ray diffraction
1.82Å resolution

Catalytic and Structural Effects of Amino-Acid Substitution at His30 in Human Manganese Superoxide Dismutase

Released:
DOI: 10.2210/pdb1n0n/pdb
PDB entry 1n0n coloured by chain, front view.
PDB entry 1n0n coloured by chain, side view.
PDB entry 1n0n coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Borgstahl GEO, Parge HE, Hickey MJ, Beyer Jr WF, Hallewell RA, Tainer JA

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137485 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Mn], mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 199 amino acids
Theoretical weight: 22.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04179 (Residues: 25-222; Coverage: 89%)
Gene name: SOD2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MN 2 x MN
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P6122
Unit cell:
a: 79.815Å b: 79.815Å c: 240.882Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.224 0.241
Expression system: Escherichia coli

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