Function and Biology Details
Reaction catalysed:
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
N-glycosylase/DNA lyase and DNA (preferred)
PDBe Complex ID:
PDB-CPX-114225 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (3 distinct):
N-glycosylase/DNA lyase
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 35.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 317 amino acids
Theoretical weight: 35.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
O15527 (Residues: 12-325; Coverage: 91%)
Sequence domains:
- 8-oxoguanine DNA glycosylase, N-terminal domain
- HhH-GPD superfamily base excision DNA repair protein
