› 1n6v

Solution NMR

Average structure of the interferon-binding ectodomain of the human type I interferon receptor

Released:
DOI: 10.2210/pdb1n6v/pdb
PDB entry 1n6v coloured by chain, front view.
PDB entry 1n6v coloured by chain, side view.
PDB entry 1n6v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding.
Chill JH, Quadt SR, Levy R, Schreiber G, Anglister J
Structure 11 791-802 (2003)
PMID: 12842042

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155758 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon alpha/beta receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 212 amino acids
Theoretical weight: 24.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48551 (Residues: 28-237; Coverage: 43%)
Gene names: IFNABR, IFNAR2, IFNARB
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Interleukin-10 and related cytokines and receptors.
Pestka et al. (2004)
9 more

4 mentions without citation

Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic.
Duncan et al. (2022)
3 more