› 1n7d

X-ray diffraction
3.7Å resolution

Extracellular domain of the LDL receptor

Released:
DOI: 10.2210/pdb1n7d/pdb
PDB entry 1n7d coloured by chain, front view.
PDB entry 1n7d coloured by chain, side view.
PDB entry 1n7d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the LDL receptor extracellular domain at endosomal pH.
Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J
Science 298 2353-8 (2002)
PMID: 12459547

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Low-density lipoprotein receptor Chain: A
Molecule details ›
Chain: A
Length: 699 amino acids
Theoretical weight: 77.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01130 (Residues: 22-720; Coverage: 83%)
Gene name: LDLR
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand CA 8 x CA
Ligand KEG 3 x KEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P3121
Unit cell:
a: 185.29Å b: 185.29Å c: 85.186Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.381 0.381 0.382
Expression system: Trichoplusia ni

Quick links

Citations

64 review citations

Reelin and brain development.
Tissir et al. (2003)
63 more

49 mentions without citation

Wnt signaling in triple-negative breast cancer.
Pohl et al. (2017)
48 more