› 1n7w

X-ray diffraction
2.2Å resolution

Crystal Structure of Human Serum Transferrin, N-Lobe L66W mutant

Released:
DOI: 10.2210/pdb1n7w/pdb
PDB entry 1n7w coloured by chain, front view.
PDB entry 1n7w coloured by chain, side view.
PDB entry 1n7w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The position of arginine 124 controls the rate of iron release from the N-lobe of human serum transferrin. A structural study.
Adams TE, Mason AB, He QY, Halbrooks PJ, Briggs SK, Smith VC, MacGillivray RT, Everse SJ
J Biol Chem 278 6027-33 (2003)
PMID: 12458193

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 36.68 KDa
Source organism: Homo sapiens
Expression system: Cricetinae
UniProt:
  • Canonical: P02787 (Residues: 22-350; Coverage: 49%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand CO3 1 x CO3
Ligand FE 1 x FE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 45.183Å b: 57.916Å c: 135.513Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.196 0.237
Expression system: Cricetinae

Quick links

Citations

3 review citations

The long history of iron in the Universe and in health and disease.
Sheftel et al. (2012)
2 more