› 1n83

X-ray diffraction
1.63Å resolution

Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor ROR(alpha)-LBD and Cholesterol

Released:
DOI: 10.2210/pdb1n83/pdb
PDB entry 1n83 coloured by chain, front view.
PDB entry 1n83 coloured by chain, side view.
PDB entry 1n83 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha.
Kallen JA, Schlaeppi JM, Bitsch F, Geisse S, Geiser M, Delhon I, Fournier B
Structure 10 1697-707 (2002)
PMID: 12467577

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152899 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor ROR-alpha Chain: A
Molecule details ›
Chain: A
Length: 270 amino acids
Theoretical weight: 31.51 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35398 (Residues: 271-523; Coverage: 48%)
Gene names: NR1F1, RORA, RZRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand CLR 1 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM1A
Spacegroup: P21
Unit cell:
a: 54.8Å b: 49.7Å c: 60.5Å
α: 90° β: 98.4° γ: 90°
R-values:
R R work R free
0.202 0.201 0.223
Expression system: Spodoptera frugiperda

Quick links

Citations

53 review citations

Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.
Jetten AM. (2009)
52 more

22 mentions without citation

REV-ERB and ROR nuclear receptors as drug targets.
Kojetin et al. (2014)
21 more