› 1n99

X-ray diffraction
1.94Å resolution

CRYSTAL STRUCTURE OF THE PDZ TANDEM OF HUMAN SYNTENIN

Released:
DOI: 10.2210/pdb1n99/pdb
PDB entry 1n99 coloured by chain, front view.
PDB entry 1n99 coloured by chain, side view.
PDB entry 1n99 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
PDZ tandem of human syntenin: crystal structure and functional properties.
Kang BS, Cooper DR, Jelen F, Devedjiev Y, Derewenda U, Dauter Z, Otlewski J, Derewenda ZS
Structure 11 459-68 (2003)
PMID: 12679023

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Syntenin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 166 amino acids
Theoretical weight: 18.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00560 (Residues: 113-273; Coverage: 54%)
Gene names: MDA9, SDCBP, SYCL
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: C2
Unit cell:
a: 100.727Å b: 48.678Å c: 74.69Å
α: 90° β: 120.82° γ: 90°
R-values:
R R work R free
0.186 0.184 0.227
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density.
Feng et al. (2009)
13 more

7 mentions without citation

Domain orientation in the N-Terminal PDZ tandem from PSD-95 is maintained in the full-length protein.
McCann et al. (2011)
6 more