› 1nap

X-ray diffraction
1.9Å resolution

THE CRYSTAL STRUCTURE OF RECOMBINANT HUMAN NEUTROPHIL-ACTIVATING PEPTIDE-2 (M6L) AT 1.9-ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1nap/pdb
PDB entry 1nap coloured by chain, front view.
PDB entry 1nap coloured by chain, side view.
PDB entry 1nap coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution.
Malkowski MG, Wu JY, Lazar JB, Johnson PH, Edwards BF
J Biol Chem 270 7077-87 (1995)
PMID: 7706245

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136198 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil-activating peptide 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 70 amino acids
Theoretical weight: 7.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02775 (Residues: 59-128; Coverage: 75%)
Gene names: CTAP3, CXCL7, PPBP, SCYB7, TGB1, THBGB1
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P1
Unit cell:
a: 40.77Å b: 43.81Å c: 44.65Å
α: 98.37° β: 120.28° γ: 92.78°
R-values:
R R work R free
0.202 0.202 0.23
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Human chemokines: an update.
Baggiolini et al. (1997)
4 more

15 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
14 more