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X-ray diffraction
2.5Å resolution

Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1

Released:
DOI: 10.2210/pdb1nav/pdb
PDB entry 1nav coloured by chain, front view.
PDB entry 1nav coloured by chain, side view.
PDB entry 1nav coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1.
Ye L, Li YL, Mellström K, Mellin C, Bladh LG, Koehler K, Garg N, Garcia Collazo AM, Litten C, Husman B, Persson K, Ljunggren J, Grover G, Sleph PG, George R, Malm J
J Med Chem 46 1580-8 (2003)
PMID: 12699376

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145479 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10827 (Residues: 148-370; Coverage: 46%)
Gene names: EAR7, ERBA1, NR1A1, THRA, THRA1, THRA2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand IH5 1 x IH5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P6522
Unit cell:
a: 109.319Å b: 109.319Å c: 134.652Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.246 0.279
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes.
Baxter et al. (2009)
15 more

15 mentions without citation

Development of Thyroid Hormones and Synthetic Thyromimetics in Non-Alcoholic Fatty Liver Disease.
Zhao et al. (2022)
14 more