› 1ncf

X-ray diffraction
2.25Å resolution

A NEW PARADIGM FOR TUMOR NECROSIS FACTOR SIGNALLING

Released:
DOI: 10.2210/pdb1ncf/pdb
PDB entry 1ncf coloured by chain, front view.
PDB entry 1ncf coloured by chain, side view.
PDB entry 1ncf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor.
Naismith JH, Devine TQ, Brandhuber BJ, Sprang SR
J Biol Chem 270 13303-7 (1995)
PMID: 7768931

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148577 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor-binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 162 amino acids
Theoretical weight: 18.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19438 (Residues: 41-201; Coverage: 38%)
Gene names: TNFAR, TNFR1, TNFRSF1A
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P41212
Unit cell:
a: 69Å b: 69Å c: 185.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.193 0.249
Expression system: Escherichia coli

Quick links

Citations

27 review citations

The TNF and TNF receptor superfamilies: integrating mammalian biology.
Locksley et al. (2001)
26 more

27 mentions without citation

Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors.
Valley et al. (2017)
26 more