› 1ncn

X-ray diffraction
2.7Å resolution

the receptor-binding domain of human B7-2

Released:
DOI: 10.2210/pdb1ncn/pdb
PDB entry 1ncn coloured by chain, front view.
PDB entry 1ncn coloured by chain, side view.
PDB entry 1ncn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling.
Zhang X, Schwartz JC, Almo SC, Nathenson SG
Proc Natl Acad Sci U S A 100 2586-91 (2003)
PMID: 12606712

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-lymphocyte activation antigen CD86 Chains: A, B
Molecule details ›
Chains: A, B
Length: 110 amino acids
Theoretical weight: 12.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42081 (Residues: 26-134; Coverage: 36%)
Gene names: CD28LG2, CD86
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P21212
Unit cell:
a: 56.69Å b: 63.01Å c: 58.61Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.258 0.214 0.278
Expression system: Escherichia coli

Quick links

Citations

21 review citations

A molecular perspective of CTLA-4 function.
Teft et al. (2006)
20 more

9 mentions without citation

Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design.
Singh et al. (2018)
8 more