Function and Biology Details
Reaction catalysed:
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
NEDD4-like E3 ubiquitin-protein ligase WWP1 (preferred)
PDBe Complex ID:
PDB-CPX-190482 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NEDD4-like E3 ubiquitin-protein ligase WWP1
Molecule details ›
Chain: A
Length: 374 amino acids
Theoretical weight: 44.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: HECT-domain (ubiquitin-transferase)
Structure domains:
Length: 374 amino acids
Theoretical weight: 44.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9H0M0 (Residues: 546-917; Coverage: 40%)
Sequence domains: HECT-domain (ubiquitin-transferase)
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE BM30A
Spacegroup:
P1
Expression system: Escherichia coli BL21(DE3)
