› 1nfa

Solution NMR

HUMAN TRANSCRIPTION FACTOR NFATC DNA BINDING DOMAIN, NMR, 10 STRUCTURES

Released:
DOI: 10.2210/pdb1nfa/pdb
PDB entry 1nfa coloured by chain, ensemble of 10 models, front view.
PDB entry 1nfa coloured by chain, ensemble of 10 models, side view.
PDB entry 1nfa coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc.
Wolfe SA, Zhou P, Dötsch V, Chen L, You A, Ho SN, Crabtree GR, Wagner G, Verdine GL
Nature 385 172-6 (1997)
PMID: 8990122

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131979 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear factor of activated T-cells, cytoplasmic 1 Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 19.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95644 (Residues: 416-591; Coverage: 19%)
Gene names: NFAT2, NFATC, NFATC1
Sequence domains: Rel homology DNA-binding domain
Structure domains: Rel homology domain (RHD), DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry
Expression system: Escherichia coli

Quick links

Citations

17 review citations

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.
Ghosh et al. (1998)
16 more

4 mentions without citation

A normalized root-mean-square distance for comparing protein three-dimensional structures.
Carugo et al. (2001)
3 more