› 1nmw

Solution NMR

Solution structure of the PPIase domain of human Pin1

Released:
DOI: 10.2210/pdb1nmw/pdb
PDB entry 1nmw coloured by chain, ensemble of 10 models, front view.
PDB entry 1nmw coloured by chain, ensemble of 10 models, side view.
PDB entry 1nmw coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the mitotic regulator hPin1 in solution: insights into domain architecture and substrate binding.
Bayer E, Goettsch S, Mueller JW, Griewel B, Guiberman E, Mayr LM, Bayer P
J Biol Chem 278 26183-93 (2003)
PMID: 12721297

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171737 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 12.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13526 (Residues: 50-163; Coverage: 70%)
Gene name: PIN1
Sequence domains: PPIC-type PPIASE domain
Structure domains: Chitinase A; domain 3

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Pinning down cell signaling, cancer and Alzheimer's disease.
Lu KP. (2004)
10 more

7 mentions without citation

Roles of Prolyl Isomerases in RNA-Mediated Gene Expression.
Thapar R. (2015)
6 more