› 1nu4

X-ray diffraction
1.8Å resolution

U1A RNA binding domain at 1.8 angstrom resolution reveals a pre-organized C-terminal helix

Released:
DOI: 10.2210/pdb1nu4/pdb
PDB entry 1nu4 coloured by chain, front view.
PDB entry 1nu4 coloured by chain, side view.
PDB entry 1nu4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
U1A RNA-binding domain at 1.8 A resolution.
Rupert PB, Xiao H, Ferré-D'Amaré AR
Acta Crystallogr D Biol Crystallogr 59 1521-4 (2003)
PMID: 12876372

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexamer
homo trimer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-140455 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
U1 small nuclear ribonucleoprotein A Chains: A, B
Molecule details ›
Chains: A, B
Length: 97 amino acids
Theoretical weight: 11.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09012 (Residues: 2-98; Coverage: 34%)
Gene name: SNRPA
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

2 bound ligands:
Ligand MG 5 x MG
Ligand MLA 12 x MLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: R32
Unit cell:
a: 91.819Å b: 91.819Å c: 120.448Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.203 0.234
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Structure and function of the Pre-mRNA splicing machine.
Sperling et al. (2008)
2 more

2 mentions without citation

In Silico Insight into Potential Anti-Alzheimer's Disease Mechanisms of Icariin.
Cui et al. (2016)
1 more