› 1o05

X-ray diffraction
2.25Å resolution

Apo form of human mitochondrial aldehyde dehydrogenase

Released:
DOI: 10.2210/pdb1o05/pdb
PDB entry 1o05 coloured by chain, front view.
PDB entry 1o05 coloured by chain, side view.
PDB entry 1o05 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Order and disorder in mitochondrial aldehyde dehydrogenase.
Hurley TD, Perez-Miller S, Breen H
Chem Biol Interact 130-132 3-14 (2001)
PMID: 11306026

Function and Biology Details

Reaction catalysed: 
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldehyde dehydrogenase, mitochondrial Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 500 amino acids
Theoretical weight: 54.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P05091 (Residues: 18-517; Coverage: 97%)
Gene names: ALDH2, ALDM
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NA 8 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 141.18Å b: 151.94Å c: 177.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.174 0.216
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

Possible role of alteration of aldehyde's scavenger enzymes during aging.
Davydov et al. (2004)
7 other articles

11 mentions without citation

Targeting aldehyde dehydrogenase 2: new therapeutic opportunities.
Chen et al. (2014)
10 more