› 1o7c

Solution NMR

Solution structure of the human TSG-6 Link module in the presence of a hyaluronan octasaccharide

Released:
DOI: 10.2210/pdb1o7c/pdb
PDB entry 1o7c coloured by chain, ensemble of 20 models, front view.
PDB entry 1o7c coloured by chain, ensemble of 20 models, side view.
PDB entry 1o7c coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding.
Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ
J Biol Chem 278 49261-70 (2003)
PMID: 12972412

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161341 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor-inducible gene 6 protein Chain: T
Molecule details ›
Chain: T
Length: 98 amino acids
Theoretical weight: 10.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P98066 (Residues: 36-133; Coverage: 38%)
Gene names: TNFAIP6, TSG6
Sequence domains: Extracellular link domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: AB INITIO SIMULATED ANNEALING
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

The C-type lectin-like domain superfamily.
Zelensky et al. (2005)
12 more

6 mentions without citation

Computation of pH-dependent binding free energies.
Kim et al. (2016)
5 more