› 1oc3

X-ray diffraction
2Å resolution

HUMAN PEROXIREDOXIN 5

Released:
DOI: 10.2210/pdb1oc3/pdb
PDB entry 1oc3 coloured by chain, front view.
PDB entry 1oc3 coloured by chain, side view.
PDB entry 1oc3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of a dimeric oxidized form of human peroxiredoxin 5.
Evrard C, Capron A, Marchand C, Clippe A, Wattiez R, Soumillion P, Knoops B, Declercq JP
J Mol Biol 337 1079-90 (2004)
PMID: 15046979

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151615 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-5, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 172 amino acids
Theoretical weight: 18.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli M15
UniProt:
  • Canonical: P30044 (Residues: 54-214; Coverage: 75%)
Gene names: ACR1, PRDX5, SBBI10
Sequence domains: Redoxin
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand BEZ 2 x BEZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: C2221
Unit cell:
a: 79.195Å b: 102.053Å c: 145.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.259
Expression system: Escherichia coli M15

Quick links

Citations

18 review citations

Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling.
Rhee et al. (2005)
17 more

7 mentions without citation

Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
Hall et al. (2011)
6 more