Function and Biology Details
Reaction catalysed:
ATP + H(2)O + 4 H(+)(Side 1) = ADP + phosphate + 4 H(+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- P-loop containing nucleoside triphosphate hydrolase
- ATP synthase, F1 complex, alpha subunit
- ATP synthase, F1 complex, gamma subunit
- ATP synthase, F1 complex, beta subunit
- ATP synthase, alpha subunit, C-terminal
- ATPase, alpha/beta subunit, nucleotide-binding domain, active site
- ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
- ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
9 more domains
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-133616 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
ATP synthase subunit alpha, mitochondrial
Molecule details ›
Chains: A, B, C
Length: 510 amino acids
Theoretical weight: 55.3 KDa
Source organism: Bos taurus
UniProt:
Sequence domains:
Length: 510 amino acids
Theoretical weight: 55.3 KDa
Source organism: Bos taurus
UniProt:
- Canonical:
P19483 (Residues: 44-553; Coverage: 92%)
Sequence domains:
- ATP synthase alpha/beta family, beta-barrel domain
- ATP synthase alpha/beta family, nucleotide-binding domain
- ATP synthase alpha/beta chain, C terminal domain
ATP synthase subunit beta, mitochondrial
Molecule details ›
Chains: D, E, F
Length: 482 amino acids
Theoretical weight: 51.76 KDa
Source organism: Bos taurus
UniProt:
Sequence domains:
Length: 482 amino acids
Theoretical weight: 51.76 KDa
Source organism: Bos taurus
UniProt:
- Canonical: P00829 (Residues: 47-528; Coverage: 91%)
Sequence domains:
- ATP synthase alpha/beta family, beta-barrel domain
- ATP synthase alpha/beta family, nucleotide-binding domain
ATP synthase subunit gamma, mitochondrial
Molecule details ›
Chain: G
Length: 272 amino acids
Theoretical weight: 30.19 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: ATP synthase
Structure domains: ATP synthase, gamma subunit, helix hairpin domain
Length: 272 amino acids
Theoretical weight: 30.19 KDa
Source organism: Bos taurus
UniProt:
- Canonical: P05631 (Residues: 26-297; Coverage: 91%)
Sequence domains: ATP synthase
Structure domains: ATP synthase, gamma subunit, helix hairpin domain
ATPase inhibitor, mitochondrial
Molecule details ›
Chain: H
Length: 84 amino acids
Theoretical weight: 9.6 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Mitochondrial ATPase inhibitor, IATP
Length: 84 amino acids
Theoretical weight: 9.6 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P01096 (Residues: 26-109; Coverage: 77%)
Sequence domains: Mitochondrial ATPase inhibitor, IATP
