› 1opl

X-ray diffraction
3.42Å resolution

Structural basis for the auto-inhibition of c-Abl tyrosine kinase

Released:
DOI: 10.2210/pdb1opl/pdb
PDB entry 1opl coloured by chain, front view.
PDB entry 1opl coloured by chain, side view.
PDB entry 1opl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the autoinhibition of c-Abl tyrosine kinase.
Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J
Cell 112 859-71 (2003)
PMID: 12654251

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-132602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ABL1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 537 amino acids
Theoretical weight: 61.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00519 (Residues: 6-12, 13-512; Coverage: 45%)
Gene names: ABL, ABL1, JTK7
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MYR 1 x MYR
Ligand P16 2 x P16
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2221
Unit cell:
a: 77.017Å b: 273.384Å c: 124.384Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.306 0.306 0.315
Expression system: Spodoptera frugiperda

Quick links

Citations

109 review citations

Targeting cancer with small molecule kinase inhibitors.
Zhang et al. (2009)
108 more

50 mentions without citation

Mechanisms of drug resistance in kinases.
Barouch-Bentov et al. (2011)
49 more